Research Article
This study concerns the results of the development of hydroxyapatites, in the field of Biomaterials, we mainly encounter ceramics, especially the uses and developments of bioactive ceramics based on calcium phosphate: hydroxyapatite (HAP), there are therefore uses of hydroxyapatite (HAP) in dental implants and filling materials and in orthopedic surgery. The objective of this work was initially, it was a new field of research that deals with more advanced ceramic materials used in Biomaterials and Nanotechnologies, the second objective was to develop hydroxyapatite of high purity from natural resources for their application. We can consider that this double objective has been achieved since on the one hand we have characterized these hydroxyapatites; on the other hand, this material is synthesized from several routes. Several techniques were used; including X-ray diffraction (XRD), scanning electron microscopy coupled with EDX microanalysis (SEM-EDX), differential thermal and gravimetric analyzes (DTA-TGA) and finally the Fourier transform infrared (FTIR) and X fluorescence (XRF).
Keywords: Hydroxyapatite, DRX, IR, Synthesis, Characterization, Porosity, Osteoconduction
Patients with diabetes mellitus often experience adverse complications, one of which is diabetic foot ulcers. Administering synthetic chemical drugs and physical treatment for wound healing and tissue regeneration deficiency in hyperglycemia is considered less effective and incurs high cost if long-term treatment is given. Ineffective therapy for diabetic foot ulcers carries the high risk of amputation and death. The development of plant-derived drugs is potential to discover effective, affordable, and safe therapy. Centella asiatica L. (C. asiatica) has wound-healing activities on the skin supported by its antibacterial, anti-inflammatory, antidiabetic, and antioxidant properties. Some of these pharmacological activities are expected to synergize in the healing process of diabetic ulcers. This review aims to reveal the supporting pharmacological activities of C. asiatica in wound healing which can be the basis for developing diabetic foot ulcer therapy. This study was conducted as a literature review through searches using the keywords "Centella asiatica", "wound healing", "antidiabetic activity", "antibacterial activity", and "antioxidant activity" from various journal articles in NCBI, PubMed, and other journal sources. The results show that C. asiatica has the potential to be developed for diabetic foot ulcer therapy with its supporting pharmacological activities, including the antidiabetic, anti-inflammatory, antioxidant, and antibacterial properties, which will improve its effectiveness in the wound-healing process.
Keywords: Centella asiatica L, diabetic ulcer, wound healing
Aromatic pandanus leaves (Pandanus amaryllifolius) are known as cooking flavoring leaves because of their aroma and biological activities that are beneficial to health. So far, there is uncertainty in using young and fresh leaves and old leaves. The phytochemical composition of P. amaryllifolius on different leaf development was used as the target in this study. GC-MS analysis revealed 16 compounds in old leaves and 21 in young ones. This study categorizes the identified compounds into several classes: phenols, prenol lipids, steroids and steroid derivatives, fatty acyls, and other metabolites. The results showed that the compound 2,6,10,14,18,22-Tetracosahexaene,2,6,10,15,19,23-hexamethyl-,(al-E)- was most dominant in old leaves and young leaves at 45.84 % and 19.22 %, respectively. International library search results show that the compound has the potential as an anti-aging and anti-tumor.
Keywords: GC-MS, metabolite, Pandanus amaryllifolius, phytochemical